To navigate, press the arrow keys. Comfort Inn is perfectly located for both business and leisure guests in Clarksdale (MS). Both business travelers and tourists can enjoy the hotel's facilities and services. Service-minded staff will welcome and guide you at the Comfort Inn. Each guestroom is elegantly furnished and equipped with handy amenities. The hotel offers various recreational opportunities. Friendly staff, great facilities and close proximity to all that Clarksdale (MS) has to offer are three great reasons you should stay at Comfort Inn.