Located in Middlesex, Comfort Inn PA Turnpike I-81 is a perfect starting point from which to explore Carlisle (PA). Offering a variety of facilities and services, the hotel provides all you need for a good night's sleep. Service-minded staff will welcome and guide you at the Comfort Inn PA Turnpike I-81. Each guestroom is elegantly furnished and equipped with handy amenities. The hotel offers various recreational opportunities. Convenience and comfort makes Comfort Inn PA Turnpike I-81 the perfect choice for your stay in Carlisle (PA).